What are ACE2 of human host cell and S-Protein of COVID-19?
How new corona virus attaches to the receptor of our host cell called angiotensin-converting enzyme 2(ACE2) of which system is also a key player of treatment of hypertension.
The tiny key molecular key (spike protein) of Covid-19 that facilitates the virus entry into the host cells and rapidly replicate the viruses into lung, kidney, gastrointestinal tract, vascular endothelial streams throughACE2.
No specific antiviral treatment drugs good for COVID-19 infection exists at present. .
Once the virus invaded into the human cells, unfortunately People infected with COVID-19 are treated with supportive care to help relieve symptoms such as steroids and other drugs but the efficacies of those drugs are questionable.
Three major drugs of treating the patients depending on their conditions.
Inhibitor drug of the adsorption of virus into host cells
Inhibitor drug of Cytokine Storm
What drugs are most effective against the patients of Covid-19?
The below drugs have been used to treat the patients at many hospitals, CIU centers in the world. However, medical doctors find difficult to what treatments are best for the fast changing disease conditioned patients with what drugs to be used.
Ciclesonide: antivirus, ant-cytokine
Tocilizumab: Anti- Cytokine Storm – IL6
Sivelestat: neutrophil elastase inhibitor, Anti-Cytokine Storm (IL6)
Avigan: an influenza antiviral drug inhibiting RNA necessary for influenza
Remdesivir: antivirus, inhibit RNA polymerase, inhibit IL6,
Nafamostat: neutrophil elastase inhibitor, anti-Cytokine Storm (Serine Elastase, IL6, IL8)
Camostat:neutrophil elastase inhibitor, Cytokine Storm
Lopinavir /ritonavir (trade name: Kaletra): – Anti-virus, Cytokine Storm
Kevzara: anti-IL-6R, Cytokine Storm
Ivermectin: Antivirus, inhibit IL6
Chloroquine and hydroxychloroquine: blocked the virus from entering and multiplying inside the cells
Approximately 65% of infected patients who took the above drugs suffered from side effect and more than 10% of the patients stopped using it due to the side effect.
Although pharmaceutical companies of the world race to find drugs that could help bring the pandemic under control, it may take a year to come up with a quality vaccine.
What is the most dreadful symptom to make infected people fall into serious pneumonia?
IT IS CYTOKINE STORM causing Sudden Crash in Patients withCOVID-19!!
TENS OF MILLIONS OF PEOPLE were killed by CYTOKINE STORMduring the pandemic of Spanish flu.
Cytokine Stormis now seen as a likely major cause of mortality in the 1918-20 “Spanish flu”–which killed more than 50 million people worldwide and the H1N1 “swine flu” in 2009and H5N1 “bird flu” of recent years—and now COVID-19.
What Cytokines are causing infected people of Covid-19 with serious lung disease?
When theCytokinesthat raise immune activity become too much abundant, the immune system is not able to stop itself. Those immune cells spread beyond infected body parts mainly from lungs and start attacking healthy tissues, gobbling up red and white blood cells and damaging the lung and liver. The blood vessels get so leaky that the lungs may fill with fluid and fall into acute respiratory distress.
Apart from a surge in main Cytokine of interleukin-6,the body may also show high swirling levels of other Cytokines,Chemokines and Serine ProteasecalledTNF, IFN-ab, IL-1, and Mcp1/CCL2. neutrophil- and monocyte-associated MMP-9, neutrophil elastase.
Dr. Randy Cron, a professor at the University of Alabama at Birmingham, says at the New York Times that “Cytokine Stormhappens when the pro-inflammatory cytokinesget out of control in abundance. Instead of helping to fight virus and bacteria, it gets overly activated and that these affluent pro-inflammatory cytokinesis what leads to multi-organ failureand potentially death.
2.BLACKCURRANT ANTHOCYANINS against VIRUS ADSORPTION and CYTOKINE STORM
Nearly 300,000 patients died in H1N1 Pandemic Influenza 2009!!
Cytokine Stormis now understood as a major cause of mortality in the 1918-20 “Spanish flu”–which killed more than 50 million peopleworldwide and the H1N1 “swine flu” and H5N1 “bird flu” of recent years—and nowCOVID-19.
The pandemic H1N1influenza of the year 2009 suddenly occurred spreading into North America, South America, Africa, European countries, Southeast Asia, Japan and widely infected more than 200 countries around the world.
British Medical Journal LANCETannounced that the US Center for Disease Control (CDC)estimated the death toll to be approximately more than 280,000worldwide.
Blackcurrant Anthocyanins significantly inhibited H1N1 Virus attached to Human Cell!!
In 2002, Asahikawa Medical Universityannounced that it had a remarkable inhibitory effect by 98% on the adsorption of influenza A and Bon human cells by Anthocyanins/phenolic of blackcurrant.
Four species of influenza were blocked to enter into human cells by blackcurrant anthocyanins!!
In the year 2013, a joint research team led by Professor Suzutani of Fukushima Medical Universityand Asahikawa Medical Universityhad disclosed studies done on the inhibition of virus adsorption that Kurokarin (blackcurrant)had a remarkable inhibitory effect of 98% inhibitionon the adsorption of pandemic influenza A (H1N1) 2009, Hong Kong influenza (IFV-AH3), Russian influenza (IFV_AH1),
Blackcurrant Anthocyanins are effectively inhibited Herpes and Adenovirus infection!!
In addition, blackcurrant anthocyanins inhibited on the cell membrane the herpes bacillus (HSV-1)and pharyngitis infecting the mouth, throat and eye area causing swelling, throat pain and high fever with high fever and throat pain.
Many studies show that Blackcurrant anthocyanins and polyphenols suppress the replication of adenovirus infectious bacteria (AdV = pool fever) that causes conjunctivitis that causes irritation of the eye, tonsillitis, eye congestion, eyes, etc.
Cytokines and Serine Proteinases causing inflammation are significantly reduced!!
Studies done at Pennsylvania University showed that the blackcurrant extract inhibited all serine proteinasestested. MMP-1 and MMP-9,inflammatory compounds of Cytokine Storm, were significantly inhibited by pure anthocyanins during 4 hours incubation test. Serine proteinases related periodontal diseasewere also significantly inhibited by pure anthocyanins.
Most Effective Adaptive Immune Response by Blackcurrant Anthocyanins
Numerous studies shows that blackcurrant anthocyanins(BA) dampen inflammation through multiple pathways. Directly or indirectly the four compositions of blackcurrant anthocyanins and polyphenols suppress the activity of nuclear transcription factors, such as NFκB, and reduce the production of pro-inflammatory enzymes and cytokines, including COX2, tumor necrosis factor (TNF)-α, and interleukin (IL)-4, 6, 8 with serine proteases while anti-inflammatory cytokines IL10 , IL13 secreted by BA support to counterbalance the adaptive immune cells in inflammatory diseases.
Pre-Clinical Data (2015 Edition by JTB):
Lab Tests Show Anthocyanins in Vision Smart Supreme Have Powerful Anti-Virus & Microbial Properties, Ideal For Virus Prevention!
Researchers showed the exact same Blackcurrant Anthocyanins extract found in Vision Smart Supreme had incredibly powerful anti-viral and anti-bacterial effects. This led researchers to state, “The findings demonstrate the potential of blackcurrant extract as a functional food for cold and flu care”!
Test Materials: Human cells in culture
Results: Blackcurrant Anthocyanins inhibited infection of cells by H1N1 2009, HSV-1 virus by
over 95%. Plus, killed over 99% of certain bacteria’s.
Institution: Fukushima Medical University School, Asahikawa Medical University, Japan.
Publican: Ikuta, K. et al (2012)
Clinical #2 (2015 Edition by JTB):
Vision Smart Supreme’s Blackcurrant Anthocyanins Help Protect and Against Influenza via Powerful Anti-inflammatory Properties!!
Norwegian researchers found Blackcurrant reduced the amounts of inflammatory compounds in the blood. These exciting results suggest Vision Smart Supreme (with the highest available does of blackcurrant anthocyanins) may be useful in protecting against Influenza.
Participants: 120 men and women
Duration: 3 weeks
Dose: 300mg Blackcurrant Anthocyanin per day
Results: Significant reduction of inflammatory compounds in the blood
Institution: University of Oslo and the Ullevaal University Hospital in Norway
Publication: Paur, P. et al. (2007)
Clinical Research: (Subjects 118)
Blackcurrants Reduce Expression of Cytokines Involved in Causing Inflammation
3.Begins in the lungs and ends in the lungs = Covid-19
COVID-19 is the same respiratory disease as influenza, and the new viral gene has many similarities with the SARS virus, so it was named SARS-CoV-2.
Specific symptoms may start with fever, cough, no smell, and no taste and eventually develop acute pneumonia like ARDS caused by Cytokine Storm.
The Lancet Medical Journalsays that 25% of people are asymptomatic but others get infected from those infected people with no symptoms and 21% of the infected people become serious ill and need mechanical ventilation to survive from ARDS. The Lancet emphasizes that in the getting ill process of infected people there are clearly three steps:
CYTOKINE STORM (IMMUNE OVERREACTION)
The coronavirus itself does not mostly and directly damage the body but their own defense system of cytokinescauses their body’s immune system to overreact, resulting in bad infections in his own lungs, heart, kidneys, which may results in multiple organ failuresuch as sepsis.
The sharpest divide came at age 70. Although 4% of patients in their 60s died, more than twice that, or 8.6%, of those in their 70s did, Covid-19 kills an estimated 14.8 % of patients 80 and older.
Covid-19 is on track to kill far more people in the United States this year than the seasonal flu.
But some people don’t even get symptoms. Recent studies suggest as many as 80 percent or more of those infected are “silent carriers”, showing no or very mild symptoms. It seems children and young, healthy people are more likely to be asymptomatic.
Boost Up an Excellent Adaptive Immune Response!!
Having a strong immune response during the incubation period can prevent the infection taking hold, reduce the actual quantity of virus in the body and prevent it from getting to the lungs.
By generating an early adaptive immune response, the body seems to recognize the virus during the incubation period and fight it off.
A person also needs to be generally healthy to be able to mount an appropriate immune response to the infection.
Less ACE 2 or More ACE 2? Important – Healthy Modulation of ACE 2
Elderly people and those with chronic lung disorders are more likely to develop ARDS and therefore to die if they got infected. This is currently thought to be due to these groups of people having fewer ACE2 receptors in their lungs.
This seems counter-intuitive, because the virus attaches itself to these receptors. However, ACE2 receptors have an important role in regulating the immune response, particularly in managing the degree of inflammation.
So the reduced levels of ACE2 receptors in the elderly may actually make them more at risk of a cytokine storm and severe lung disease.
Please Stay Safe and Healthy For Yourself and Your Family!!
Please be advised that we haven’t tested blackcurrant anthocyanins on the cell adsorption and/or Cytokine Storm in vitro or by human. However, Blackcurrant anthocyanins contained in Vision Smart Supreme support to improve our immune system by taking it for a while from many studies done in the past 20 years.